Subgingival triclosan-polydimethylsiloxane gel as an adjunct to scaling and root planing.

Abstract

PURPOSE:

To evaluate the influence of a triclosan-polydimethylsiloxane-containing gel when used as an adjunct to scaling and root planing on the treatment of chronic periodontal disease.

METHODS:

A 3-month, double-blind, randomized parallel design clinical trial was performed in 20 subjects with chronic periodontitis. The subjects, presenting at least three anterior sites with probing depth (PD) +/- 5 mm and bleeding on probing (BoP), were randomly assigned to two experimental groups: Group SRP-T: scaling/root planing plus test gel application (triclosan 1% + polydimethylsiloxane 13%) or Group SRP: scaling/root planing plus control gel application (polydimethylsiloxane 13%). Immediately following mechanical therapy, each assigned gel was applied to the selected sites and once a week during the following 3 weeks. Re-examinations were carried out on days 45 and 90 after the last irrigation.

RESULTS:

Significant reductions in PD and clinical attachment level (CAL) were observed for both groups in both periods (P < 0.05). However, SRP-T showed lower means of PD than SRP at Day 45 (3.60 +/- 0.87 versus 4.77 +/- 1.38, respectively, P = 0.035) and CAL at both 45 days (4.63 +/- 1.17 versus 6.07 +/- 1.43, P = 0.023) and 90 days (4.45 +/- 1.19 versus 5.91 +/- 1.37, P = 0.021). No differences were found for bleeding on probing, plaque index and gingival recession (P > 0.05) between groups.

• Authors: Giovana Lecio, Luciana M Shaddox, Marcelo Diniz Carvalho, Poliana Mendes Duarte, Roberto Santos Tunes, Getulio Rocha Nogueira-Filho, Enilson Antonio Sallum
• Journal: American journal of dentistry (Am J Dent) Vol. 21 Issue 3 Pg. 171-4 (Jun 2008) ISSN: 0894-8275 [Print] United States
• PMID: 18686769 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents, Local
• Dimethylpolysiloxanes
• Triclosan
• baysilon

Topics

• Administration, Topical
• Adult
• Anti-Infective Agents, Local (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Dental Plaque Index
• Dental Scaling
• Dimethylpolysiloxanes (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Follow-Up Studies
• Gingival Hemorrhage (drug therapy, therapy)
• Gingival Recession (drug therapy, therapy)
• Humans
• Male
• Periodontal Attachment Loss (drug therapy, therapy)
• Periodontal Pocket (drug therapy, therapy)
• Periodontitis (drug therapy, therapy)
• Root Planing
• Triclosan (administration & dosage, therapeutic use)