[Effects of Feiji Formula on lung cancer metastasis in mice].

Abstract

OBJECTIVE:

To observe the effects of Feiji Formula, a compound traditional Chinese herbal medicine, on lung cancer metastasis in mice.

METHODS:

The lung cancer metastasis model of mice was established in this experiment study. Twenty-four mice were randomly divided into three groups: untreated group, cisplatin group and Feiji Formula group. Mice in the Feiji Formula group were treated with Feiji Formula decoction; in cisplatin group, with cisplatin by intraperitoneal injection; and in the untreated group, with normal saline (NS). After twenty-day treatment, the body and tumor weights as well as the number of metastatic tumors in both lungs of each mouse were measured.

RESULTS:

The body weight of mice in cisplatin group was significantly less than that of Feiji Formula group and untreated group (P<0.01); the tumor weight of mice in cisplatin group and Feiji Formula group was markedly lower than that of untreated group (P<0.01); and the number of metastatic tumors in cisplatin group and Feiji Formula group was markedly lower than that of the untreated group (P<0.01), no significant difference between the Feiji Formula group and cisplatin group in terms of the weights and the numbers of metastatic tumors in bilateral lungs.

CONCLUSION:

Feiji Formula can suppress tumor growth and decrease the number of lung metastatic tumors in the mice, and maintain the body weight of the mice.

• Authors: Jian-hui Tian, Zhi-ming Shi, Zhi-yi Zhou, Yun-sheng Huang, Lin Wang
• Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine (Zhong Xi Yi Jie He Xue Bao) Vol. 6 Issue 8 Pg. 827-9 (Aug 2008) ISSN: 1672-1977 [Print] China
• PMID: 18664352 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• feiji

Topics

• Animals
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Carcinoma, Lewis Lung (drug therapy)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Lung Neoplasms (drug therapy)
• Male
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis (prevention & control)
• Phytotherapy
• Random Allocation