Abstract | OBJECTIVE: To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease. DESIGN: A controlled clinical study and an in vitro study. SETTING: Department of Obstetrics and Gynecology, Tottori University, Japan. PATIENT(S): INTERVENTION(S): MAIN OUTCOME MEASURE(S):
Interleukin-8 concentration in the serum or supernatant of the cell culture was measured with use of ELISA. RESULT(S): The serum concentration of IL-8 in patients with endometrioma was significantly higher than in patients with benign ovarian cyst. The serum IL-8 threshold (25 pg/mL) had a higher sensitivity (71.4%) for diagnosing ovarian endometrioma than did serum CA-125 level. The increased rates of IL-8 concentration in the culture supernatants after adding tumor necrosis factor alpha were significantly higher in patients whose serum IL-8 levels were >or=25 pg/mL than in those with levels <25 pg/mL. CONCLUSION(S): Measuring of serum IL-8 concentration may be a valuable tool in diagnosing endometriosis.
|
Authors | Yorie Ohata, Tasuku Harada, Hiroko Miyakoda, Fuminori Taniguchi, Tomio Iwabe, Naoki Terakawa |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 90
Issue 4
Pg. 994-9
(Oct 2008)
ISSN: 1556-5653 [Electronic] United States |
PMID | 18635170
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Endometriosis
(blood, diagnosis)
- Female
- Humans
- Interleukin-8
(blood)
- Middle Aged
- Ovarian Diseases
(blood, diagnosis)
- Reproducibility of Results
- Sensitivity and Specificity
|