[The influence of polyvitamin complex polijen on mutagenic and cytotoxic effect of copper oxychloride in white mice].

Abstract

The present study investigates antimutagenic and anticytotoxic effect of polyvitamin complex Polijen in laboratory mice. Mutation in mice was induced by pesticide - copper oxychloride 3Cu(OH)2 CuCl2 , which is characterizes by the mutagenic and cytotoxic effect. Introduction of copper oxychloride (dosage 1/2, 1/5, 1/10 LD50) per oral to animals induces strong increase (p<0,001) of frequency of chromosomal aberrations (multiple fragments, lyses), genomic mutations (triploidy, tetraploidy), pathological mitosis (hollow metaphase, K-mitosis, adhesion of chromosomes) and destruction of interphase nucleuses (hollow nucleus). Experiments showed that administration of polyvitamin complex Polijen decreased 2, 5 times mutagenic and cytotoxic effect of pesticide-copper oxychloride.

• Authors: A G Pirtskhelani, N A Pirtskhelani, R A Gakhokidze, N V Bichikashvili, E A Kalandiia
• Journal: Georgian medical news (Georgian Med News) Issue 159 Pg. 44-7 (Jun 2008) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 18633151 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Vitamins
• copper oxychloride
• Copper

Topics

• Animals
• Chromosome Aberrations (chemically induced, drug effects)
• Copper (toxicity)
• Disease Models, Animal
• Mice
• Mutation (drug effects)
• Treatment Outcome
• Vitamins (therapeutic use)