Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: The most growth inhibition was observed in the co-administration group. When three different dosing schedules of caffeine were given, the extent of tumor inhibition was closely correlated with the average plasma concentration of caffeine. The cisplatin concentration in the tumor was significantly increased when caffeine was co-administered. CONCLUSION: This study confirms that a high concentration of caffeine (about 0.4 mM) is effective in enhancing the antitumor effects of cisplatin.
|
Authors | Masami Kawahara, Yuri Takahashi, Kotaro Takazawa, Hiroyuki Tsuchiya, Katsuro Tomita, Koichi Yokogawa, Ken-ichi Miyamoto |
Journal | Anticancer research
(Anticancer Res)
2008 May-Jun
Vol. 28
Issue 3A
Pg. 1681-5
ISSN: 0250-7005 [Print] Greece |
PMID | 18630526
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(blood, pharmacokinetics, pharmacology)
- Bone Neoplasms
(blood, drug therapy, metabolism)
- Caffeine
(administration & dosage, blood, pharmacology)
- Cisplatin
(administration & dosage, blood, pharmacokinetics, pharmacology)
- Dose-Response Relationship, Drug
- Drug Synergism
- Male
- Osteosarcoma
(blood, drug therapy, metabolism)
- Rats
- Rats, Inbred F344
- Tissue Distribution
|