Abstract | OBJECTIVE: DESIGN: Prospective study. SETTING: Tertiary-care academic medical center. PATIENTS: INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:
NT-proBNP was measured from blood taken within 48 hrs of acute respiratory distress syndrome onset. Patients were followed for the primary outcome of 60-day mortality and secondary outcomes of organ dysfunction and ventilator-free days. Seventy patients died (40%). Median NT-proBNP level was 3181 ng/L (interquartile range 723-9246 ng/L). NT-proBNP levels were significantly higher among nonsurvivors (p < .0001). Receiver operating curve analysis revealed an optimal NT-proBNP cut-point of 6813 ng/L for predicting death. Patients with levels above the cut-point had significantly higher odds of mortality on multivariable analysis (odds ratio 2.36, 95% confidence interval 1.11-4.99, p = .02) than those with levels below the cut-point. Kaplan-Meier survival analysis showed that this difference emerged early and was sustained (p < .0001). Patients with elevated NT-proBNP also had higher organ dysfunction scores (p < .0001) and fewer ventilator free days (p = .03) than those with lower NT-proBNP levels. CONCLUSIONS:
|
Authors | Ednan K Bajwa, James L Januzzi, Michelle N Gong, B Taylor Thompson, David C Christiani |
Journal | Critical care medicine
(Crit Care Med)
Vol. 36
Issue 8
Pg. 2322-7
(Aug 2008)
ISSN: 1530-0293 [Electronic] United States |
PMID | 18596623
(Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Biomarkers
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
|
Topics |
- APACHE
- Aged
- Biomarkers
- Female
- Humans
- Intensive Care Units
- Logistic Models
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Prognosis
- Prospective Studies
- Respiratory Distress Syndrome
(blood, mortality, physiopathology)
- Survival Analysis
|