Review: Deoxyglucose compounds labeled with isotopes different from 18-fuoride: is there a future in clinical practice?

Abstract

There are several radionuclide-labeled derivatives of deoxyglucose (DG) that have been developed including 2-fluro-deoxyglucose, ethylenedicysteine-deoxyglucose, diethylenetriaminepentaacetate-deoxyglucose, N-(2'-hydroxybenzyl)-2-amino-2-deoxy-D-glucose, and methyl D-glucoside that were synthesized and successfully labeled in high labeling fields. The former 4 were used for tumor imaging and methyl-D-glucoside for the diagnosis and the monitoring of the functional status of renal tubules. These derivatives are suitable for imaging examinations when labeled with either fluorine-18 (18F), technetium-99m (99mTc), carbon-11 (11C), or gallium-68 (68Ga). These compounds are suitable both for imaging and for therapy if labeled with rhenium-188 (188Re). In the area of molecular imaging of nuclear medicine, derivatives of radionuclide-labeled deoxyglucose will become an important tool for the diagnosis and carcinoma treatment in the clinic.

• Authors: Qing-Feng Xiong, Yue Chen
• Journal: Cancer biotherapy & radiopharmaceuticals (Cancer Biother Radiopharm) Vol. 23 Issue 3 Pg. 376-81 (Jun 2008) ISSN: 1557-8852 [Electronic] United States
• PMID: 18593371 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Fluorine Radioisotopes
• Radioisotopes
• Fluorodeoxyglucose F18
• Rhenium
• Technetium
• Pentetic Acid
• Deoxyglucose

Topics

• Animals
• Deoxyglucose (chemistry, metabolism, pharmacology)
• Diagnostic Imaging (methods)
• Fluorine Radioisotopes (pharmacology)
• Fluorodeoxyglucose F18 (pharmacology)
• Humans
• Mice
• Neoplasm Transplantation
• Neoplasms (diagnosis, radiotherapy)
• Pentetic Acid (pharmacology)
• Positron-Emission Tomography (instrumentation, methods)
• Radioisotopes (chemistry, pharmacology)
• Rhenium (pharmacology)
• Technetium (metabolism)
• Tomography, Emission-Computed, Single-Photon (instrumentation, methods)