[Protective effect of Yiqi Mingmu solution on rat's retina with ischemia reperfusion injury].

Abstract

OBJECTIVE:

To investigate the protective effect of the Yiqi Mingmu solution irrigated into rat on retinal injury of rat induced by ischemia reperfusion.

METHODS:

SD rats were divided into four groups randomly: negative control group, model control group, low and high dose group. Increasing the intraocular pressure with anterior chambers infused liquid induced the models of retinal ischemia reperfusion of rats. Different doses of Yiqi Mingmu solution were respectively irrigated into rats 7 days before ischemia in low and high dose group. Normal salire instead was used in normal and model control group. At 1, 3, 7, 15 days after the ischemia reperfusion injury, the content of MDA and activity of SOD in rat's retina were measured. The histopathologic changes were observed with transmission electron microscopy and light microscopy.

RESULTS:

At 3, 7, 15 days after the ischemia reperfusion injury, the activity of SOD in Yiqi Mingmu solution low and high dose group were higher than in the model control group, the content of MDA in Yiqi Mingmu solution high dose group were lower than in the model control group. The histopathologic injury of retina in the Yiqi Mingmu solution low and high dose group were less than in the model control group.

CONCLUSION:

Yiqi Mingmu solution has protective effect on rat's retina ischemia reperfusion injury, and it is an effective traditional Chinese recipe to treat the diseases of retina ischemia.

• Authors: Xi-lan Tang, Yan-dong Wang, Chu-long Huang, Wei Wu
• Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (Zhong Yao Cai) Vol. 31 Issue 1 Pg. 91-4 (Jan 2008) ISSN: 1001-4454 [Print] China
• PMID: 18589759 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• yiqi mingmu
• Malondialdehyde
• Superoxide Dismutase

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (administration & dosage, chemistry, pharmacology)
• Female
• Male
• Malondialdehyde (metabolism)
• Microscopy, Electron
• Plants, Medicinal (chemistry)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Reperfusion Injury (pathology, prevention & control)
• Retina (drug effects, metabolism, pathology)
• Retinal Ganglion Cells (drug effects, pathology, ultrastructure)
• Superoxide Dismutase (metabolism)