Abstract |
In this study we have investigated various morphofunctional features of gallbladder mucosa in patients with uncomplicated cholelithiasis. The histological changes, endocrine cell types and their distribution, and mucin-producing cells were characterized by immunocytochemistry and mucin histochemistry; moreover, we attempted to correlate these findings to the number and size of gallbladder stones and the type of bacteria present in the bile. Our results indicate that, despite similar clinical parameters, a wide range of histological changes can occur in the gallbladder mucosa of these patients. Moreover, the presence of certain endocrine and mucin-producing cell types in so-called "pyloric metaplasia" led us to hypothesize that this finding may be a trivial event in the gallbladder epithelium.
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Authors | F Carlei, N J Lygidakis, P Barsotti, A Crescenzi, C Natellis, F Carotenuto, E Dorsi, C U Casciani |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
Vol. 38
Issue 2
Pg. 149-53
(Apr 1991)
ISSN: 0172-6390 [Print] Greece |
PMID | 1855773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Cholelithiasis
(pathology)
- Epithelium
(pathology)
- Female
- Gallbladder
(metabolism, pathology)
- Humans
- Immunoenzyme Techniques
- Middle Aged
- Mucins
(biosynthesis)
- Mucous Membrane
(pathology)
- Mucus
(metabolism)
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