Abstract | BACKGROUND AND OBJECTIVE: METHOD: Thirty patients (28 women, 2 men), aged 18 to 48 years with migraine according the International Headache Society (IHS) (2004) were studied. The patients were randomized into 2 groups when presenting to an emergency department with a severe migraine attack. The study was single-blind. Headache intensity, nausea, photophobia and side effects were evaluated at 0, 30, 60 and 90 minutes after the drug administration. Rectal indomethacin as rescue medication (RM) was available after 2 hours and its use compared between groups. RESULTS: All patients completed the study. At 30 minutes, 0% of the dipyrone group 13% of the LC group were pain free (p=0.46). At 60 and 90 minutes, 2 (13%) and 5 (33%) patients from the dipyrone group and 11 (73%) and 13 (86.7%) patients from the LC group were pain free (p<0.001). At 60 minutes, significantly more patients from the LC group were nausea-free (p<0.001). Regarding photophobia, there were no differences between groups at 60 minutes (p=0.11). The use of RM at 2 hours did not differ among groups (p=0.50). Pain in the site of the injection was reported by more patients of the LC group compared to the dipyrone group (p<0.0001). CONCLUSION: LC is significantly superior to dipyrone in treating severe migraine attacks. LC promotes significantly more burning at the site of the injection.
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Authors | Abouch Valenty Krymchantowski, Henrique Carneiro, Jackeline Barbosa, Carla Jevoux |
Journal | Arquivos de neuro-psiquiatria
(Arq Neuropsiquiatr)
Vol. 66
Issue 2A
Pg. 216-20
(Jun 2008)
ISSN: 0004-282X [Print] Germany |
PMID | 18545786
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- lysine clonixinate
- Dipyrone
- Lysine
- Clonixin
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Topics |
- Acute Disease
- Adolescent
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Clonixin
(adverse effects, analogs & derivatives, therapeutic use)
- Dipyrone
(adverse effects, therapeutic use)
- Female
- Humans
- Lysine
(adverse effects, analogs & derivatives, therapeutic use)
- Male
- Middle Aged
- Migraine Disorders
(drug therapy)
- Pain Measurement
- Severity of Illness Index
- Single-Blind Method
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