Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.

Abstract

The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.

• Authors: Leonor Varela-Lema, Emanuela Taioli, Alberto Ruano-Ravina, Juan M Barros-Dios, Devasena Anantharaman, Simone Benhamou, Stefania Boccia, Rajani A Bhisey, Gabriella Cadoni, Ettore Capoluongo, Chien-Jen Chen, William Foulkes, Eny Maria Goloni-Bertollo, Ana Hatagima, Richard B Hayes, Takahiko Katoh, Sergio Koifman, Phillip Lazarus, Johannes J Manni, Manoj Mahimkar, Shunji Morita, Jong Park, Kwang-Kyun Park, Erika Cristina Pavarino Bertelli, Enilze Maria de Souza Fonseca Ribeiro, Bidyut Roy, Margaret R Spitz, Richard C Strange, Qingyi Wei, Camille C Ragin
• Journal: Genetics in medicine : official journal of the American College of Medical Genetics (Genet Med) Vol. 10 Issue 6 Pg. 369-84 (Jun 2008) ISSN: 1530-0366 [Electronic] United States
• PMID: 18496222 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Cytochrome P-450 CYP1A1
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Alleles
• Case-Control Studies
• Cytochrome P-450 CYP1A1 (genetics)
• Exons
• Genetic Predisposition to Disease
• Glutathione Transferase (genetics)
• Homozygote
• Humans
• Mouth Neoplasms (ethnology, genetics)
• Odds Ratio
• Pharyngeal Neoplasms (ethnology, genetics)
• Polymorphism, Genetic
• Tobacco Use Disorder (complications)