[Analgesic activity of dipeptide Tyr-Pro].

Abstract

The effect of dipeptide Tyr-Pro, present in representatives of most families of opioid peptides, and two its analogs, Tyr-Pro-NH2 and Tyr-Pro-OMe, on analgesic activity was studied in different tests (tail-flick test, tail pinch (Haffner's) test, formalin test, and acetic acid writing test) describing different organization levels of pain sensitivity. Intraperitoneal administration of the dipeptide decreased the pain threshold in all above-mentioned tests. Coadministration of the dipeptide and naloxone or naloxone methiodide insignificantly decreased the dipeptide analgesic effect in the tail-flick and acetic acid writing tests. Its analogs Tyr-Pro-NH2 and Tyr-Pro-OMe demonstrated a similar analgesic activity in the tail-flick test and a higher activity in the acetic acid writing test. Administration of individual amino acids (Tyr or Pro) or their mixture had no effect on the pain threshold.

• Authors: L S Guzevatykh, T A Voronina, T G Emel'ianova, L A Andreeva, L Iu Alfeeva, S B Seredenin, N F Miasoedov
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2008 Jan-Feb Issue 1 Pg. 61-7 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 18491563 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Analgesics, Opioid
• Dipeptides
• tyrosyl-proline
• Naloxone

Topics

• Analgesics (administration & dosage, pharmacology)
• Analgesics, Opioid (pharmacology)
• Animals
• Dipeptides (administration & dosage, pharmacology)
• Male
• Mice
• Naloxone (administration & dosage, pharmacology)
• Nociceptors (physiology)
• Pain Measurement
• Pain Threshold (drug effects)
• Rats