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tyrosyl-proline (Tyr-Pro)

Also Known As:

Tyr-Pro; YP dipeptide; tyrosylproline

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - tyrosyl-proline: 14

Experts

1.	Lazarus, Lawrence H: 2 articles (06/2008 - 01/2002)
2.	Okada, Yoshio: 2 articles (06/2008 - 01/2002)
3.	Gao, Zhuanglei: 1 article (04/2020)
4.	Li, Bo: 1 article (04/2020)
5.	Li, Guanghua: 1 article (04/2020)
6.	Song, Jingang: 1 article (04/2020)
7.	Wang, Na: 1 article (04/2020)
8.	Sukumwang, Neelanun: 1 article (08/2013)
9.	Umezawa, Kazuo: 1 article (08/2013)
10.	Goldberg, Joel S: 1 article (01/2011)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 04/27/2020 - "This study aimed to investigate the effects of the structural analog of endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH₂) on human colon cancer cells in vitro. "
2.	Pain (Aches) 01/01/2002 - "Opioidmimetics and opioid peptides containing the amino acid sequence of the message domain of endomorphins, Tyr-Pro-Phe/Trp, could exhibit unique binding activity and lead to the development of new therapeutic drugs for controlling pain." 01/01/2008 - "The effect of dipeptide Tyr-Pro, present in representatives of most families of opioid peptides, and two its analogs, Tyr-Pro-NH2 and Tyr-Pro-OMe, on analgesic activity was studied in different tests (tail-flick test, tail pinch (Haffner's) test, formalin test, and acetic acid writing test) describing different organization levels of pain sensitivity. "
3.	Hyperalgesia 01/01/2011 - "Preliminary animal data suggests that tyr-pro-ethyl ester crosses the BBB and unexpectedly produces hyperalgesia. " 04/25/2003 - "Hyperalgesia was significantly inhibited by N-[2-(4-chlorophenyl) ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide (capsazepine), a vanilloid receptor antagonist, by the local administration of pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Pro (spiro-gamma-lactam) Leu-Trp-NH(2) (GR82334) or of Phenyl-CO-Ala-Ala-D-Trp-Phe-D-Pro-Pro-Nle-NH(2) (GR94800), inhibitors of tachykinin NK(1) and NK(2) receptors, respectively, or by the local injection of dizocilpine (MK 801), (+/-)-2-amino-5-phosphonopentanoic acid ((+/-)-AP-5), or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), antagonists of NMDA and non-NMDA excitatory amino acid receptors. "
4.	Prolidase Deficiency 05/18/1990 - "The quasi-molecular ions [M + H]+ of various iminodipeptides were also observed in the urine samples of patients with prolidase deficiency, and Gly-Pro, Ala-Pro, Val-Pro, Leu-Pro, Ile-Pro, Ser-Pro, Thr-Pro, Glu-Pro, Asp-Pro, His-Pro, Lys-Pro, Pro-Pro and Tyr-Pro as iminodipeptides containing proline with C-terminal residue and Glu-Hyp, Pro-Hyp, Ile-Hyp and Gly-Hyp as iminodipeptides containing hydroxyproline with C-terminal residue were identified in the urine of patients with prolidase deficiency."
5.	Tics (Tic) 04/05/1996 - "The scope of this investigation included the cis-trans isomers of the dipeptides Leu-Pro, Phe-Pro and Tyr-Pro as well as conformers of opioid peptides containing proline and/or the proline-like Tic (1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid) residues: Tyr-Pro-Phe (beta-casomorphin 1-3 fragment), Tyr-Tic-Phe-Phe, Try-Pro-Phe-Pro-Gly (beta-casomorphin-5), Tyr-Tic-Phe-Phe-Val-Val-Gly-NH2 and Tyr-Tic-Phe-Gly-Tyr-Pro-Ser-NH2. "

Related Drugs and Biologics

1.	phenylalanylphenylalanine
2.	endomorphin 2
3.	Opioid Peptides (Opioid Peptide)
4.	Proline (L-Proline)
5.	Peptides (Polypeptides)
6.	Dipeptides
7.	Amino Acids
8.	aspartyl-proline (Asp-Pro)
9.	histidylglycine
10.	TRPV Cation Channels

Related Therapies and Procedures

1.	Oral Administration