Type 1 interferons cool the inflamed brain.

Abstract

Although interferon-beta is the most popular treatment for multiple sclerosis, its mechanism of action remains enigmatic. In this issue of Immunity, Prinz et al. (2008) elucidate an intriguing portrait of the pleiotropic effects of type 1 interferons in taming brain inflammation.

• Authors: Robert C Axtell, Lawrence Steinman
• Journal: Immunity (Immunity) Vol. 28 Issue 5 Pg. 600-2 (May 2008) ISSN: 1097-4180 [Electronic] United States
• PMID: 18482563 (Publication Type: Comment, Journal Article)

Chemical References

• Cytokines
• Histocompatibility Antigens Class II
• Receptor, Interferon alpha-beta
• Interferon-beta

Topics

• Adoptive Transfer
• Animals
• Autoimmunity
• B-Lymphocytes (immunology, metabolism)
• Brain (immunology)
• CD4-Positive T-Lymphocytes (immunology, metabolism)
• Cytokines (immunology, metabolism)
• Encephalomyelitis, Autoimmune, Experimental (immunology, metabolism)
• Histocompatibility Antigens Class II (metabolism)
• Humans
• Interferon-beta (immunology, metabolism)
• Mice
• Microglia (immunology, metabolism)
• Multiple Sclerosis (immunology, metabolism)
• Myelin Sheath (immunology)
• Myeloid Cells (immunology, metabolism)
• Phagocytosis
• Receptor, Interferon alpha-beta (immunology, metabolism)
• Signal Transduction
• Up-Regulation