Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma.

Abstract

We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.

• Authors: Jianjun Chen, Zhao Wang, Yan Lu, James T Dalton, Duane D Miller, Wei Li
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 11 Pg. 3183-7 (Jun 01 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18477505 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Imidazoles
• Imidazolines
• Thiazolidines

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Humans
• Imidazoles (chemical synthesis, pharmacology)
• Imidazolines (chemical synthesis, pharmacology)
• Melanoma (pathology)
• Structure-Activity Relationship
• Thiazolidines (chemical synthesis, pharmacology)