Carotid artery intima-media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis.

Abstract

In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima-media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.

• Authors: Yaniv Sherer, Christian Pagnoux, Gilles Chironi, Alain Simon, Loïc Guillevin, Luc Mouthon, Boris Gilburd, Yehuda Shoenfeld
• Journal: Rheumatology international (Rheumatol Int) Vol. 28 Issue 11 Pg. 1099-103 (Sep 2008) ISSN: 0172-8172 [Print] Germany
• PMID: 18443794 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Chaperonin 60
• Heat-Shock Proteins
• Immunoglobulin M
• Lipoproteins, LDL
• heat-shock protein 65, human
• oxidized low density lipoprotein

Topics

• Adult
• Aged
• Autoantibodies (blood)
• Carotid Artery, Common (pathology)
• Case-Control Studies
• Chaperonin 60 (immunology)
• Female
• Heat-Shock Proteins (immunology)
• Humans
• Immunoglobulin M
• Lipoproteins, LDL (immunology)
• Lupus Erythematosus, Systemic
• Male
• Middle Aged
• Tunica Intima (pathology)
• Tunica Media (pathology)
• Vasculitis (immunology, pathology)