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Molecular basis of Laron dwarfism.

Abstract
An autosomal recessive disorder, Laron-type dwarfism, results from peripheral unresponsiveness to growth hormone. Mutations in the growth hormone receptor have recently been identified in this syndrome. Analysis of patients with Laron-type dwarfism should provide insight into the mechanisms of hormone receptor binding and signal transduction pathways of this receptor, which belongs to a new class of transmembrane receptors.
AuthorsS Amselem, P Duquesnoy, M Goossens
JournalTrends in endocrinology and metabolism: TEM (Trends Endocrinol Metab) 1991 Jan-Feb Vol. 2 Issue 1 Pg. 35-40 ISSN: 1043-2760 [Print] United States
PMID18411163 (Publication Type: Journal Article)

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