Regression of herpes viral infection symptoms using melatonin and SB-73: comparison with Acyclovir.

Abstract

Infection with Herpes simplex virus type 1 (HSV-1) typically causes lesions of the mouth, face, skin, esophagus, or brain. Herpes simplex virus type 2 (HSV-2) usually causes infections of the genitals, rectum, skin, hands, or meninges. The herpes viruses are a major cause of blindness from keratitis. The usual drugs used for herpes are Vidarabine, Acyclovir, Penciclovir and Ganciclovir; they are associated with several complications. The aim of this study was to investigate if a formulation containing 2.5 mg melatonin and 100 mg SB-73 would help patients with herpes, and to compare the preparation with 200 mg Acyclovir. SB-73 is a mixture of magnesium, phosphate, fatty acids extracted from Aspergillus sp. which has anti-herpes virus properties. A single blind randomized study was performed in which 70 patients underwent treatment using the supplement cited above (group A) and 75 received treatment of 200 mg Acyclovir (group B). Sixty-seven patients of the group A (95.7%) reported a complete regression of symptoms after 7 days of treatment. By comparison, 64 subjects (85.3%) of the Acyclovir reported regression of symptoms in the same period. There was statiscally significant difference between the groups (P < 0.05).

• Authors: Odilon da Silva Nunes, Ricardo de Souza Pereira
• Journal: Journal of pineal research (J Pineal Res) Vol. 44 Issue 4 Pg. 373-8 (May 2008) ISSN: 1600-079X [Electronic] England
• PMID: 18410585 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Central Nervous System Depressants
• Linoleic Acids
• Organophosphorus Compounds
• magnesium ammonium phospholinoleate anhydride
• Melatonin
• Acyclovir

Topics

• Acyclovir (administration & dosage)
• Adult
• Antiviral Agents (administration & dosage)
• Blindness (drug therapy, etiology, pathology, virology)
• Central Nervous System Depressants (administration & dosage)
• Female
• Herpes Genitalis (complications, drug therapy, pathology)
• Herpesvirus 1, Human
• Herpesvirus 2, Human
• Humans
• Keratitis (drug therapy, etiology, pathology, virology)
• Linoleic Acids (administration & dosage)
• Male
• Melatonin (administration & dosage)
• Organophosphorus Compounds (administration & dosage)
• Single-Blind Method