Abstract | OBJECTIVES: METHODS: RESULTS: In patients with anti-CCP-positive arthralgia, the frequency of SE allele positivity is significantly lower when compared with anti-CCP-positive early arthritis and established RA (58% vs 80%, and 58% vs 92%, respectively, both p<0.001). Median anti-CCP levels were higher in the group of patients with SE-positive arthralgia compared with the group of patients with SE-negative arthralgia (p = 0.02). Median anti-CCP levels were similar in the groups of patients with SE-positive arthralgia and arthritis. CONCLUSIONS: The lower frequency of SE positivity in patients with arthralgia compared with patients with RA indicates that, compared with patients who were SE positive, patients who were SE negative as a group go through a longer arthralgia phase, or alternatively have a lower risk for transition from anti-CCP positive arthralgia to RA. Furthermore, the present results suggest that in this early stage the effect of the SE on disease risk may be mediated through higher anti-CCP levels.
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Authors | W H Bos, J Ursum, N de Vries, G M Bartelds, G J Wolbink, M T Nurmohamed, I E van der Horst-Bruinsma, R J van de Stadt, J B A Crusius, P P Tak, B A C Dijkmans, D van Schaardenburg |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 67
Issue 9
Pg. 1347-50
(Sep 2008)
ISSN: 1468-2060 [Electronic] England |
PMID | 18388157
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Biomarkers
- Epitopes
- HLA-DR Antigens
- HLA-DRB1 Chains
- Peptides, Cyclic
- cyclic citrullinated peptide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arthralgia
(immunology)
- Arthritis
(immunology)
- Arthritis, Rheumatoid
(immunology)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Disease Progression
- Epitopes
(immunology)
- Female
- HLA-DR Antigens
(immunology)
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Peptides, Cyclic
(immunology)
- Risk Factors
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