Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome.

Abstract

OBJECTIVES:

The objective of this study were (1) to evaluate the prevalence of anti-annexin II antibodies in patients with various autoimmune diseases and antiphospholipid syndrome and (2) to correlate anti-annexin II antibodies with anti-phospholipid antibodies.

MATERIALS AND METHODS:

Anti-annexin II antibodies and anti-phospholipid were detected, using an enzyme-linked immunosorbent assay, in the serum of patients with primary antiphospholipid syndrome (n = 16), systemic lupus erythematosus (n = 53), primary Sjögren syndrome (n = 71), systemic sclerosis (n = 17), systemic vasculitis (n = 18), and rheumatoid arthritis (n = 119). Healthy blood donors (n = 99) were used as controls.

RESULTS:

Anti-annexin II antibodies were significantly more prevalent in patients with connective tissue diseases (8.5%), especially antiphospholipid syndrome (14.8%) and rheumatoid arthritis (10%), than in controls (2%). An inverse correlation was observed between anti-annexin II antibodies and antiphospholipid antibodies.

CONCLUSION:

Annexin II can be recognized by antibodies in serum from patients with systemic autoimmune disorders. Further studies are required to determine the clinical significance of anti-annexin II antibodies in rheumatoid arthritis and to determine their diagnostic value in discriminating clinical subgroups of patients with antiphospholipid syndrome.

• Authors: V Salle, J C Mazière, A Smail, R Cévallos, C Mazière, V Fuentes, B Tramier, R Makdassi, G Choukroun, O Vittecoq, V Goëb, J P Ducroix
• Journal: Journal of clinical immunology (J Clin Immunol) Vol. 28 Issue 4 Pg. 291-7 (Jul 2008) ISSN: 0271-9142 [Print] Netherlands
• PMID: 18322784 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ANXA2 protein, human
• Annexin A2
• Antibodies, Antiphospholipid
• Autoantibodies
• Autoantigens

Topics

• Adult
• Aged
• Annexin A2 (immunology)
• Antibodies, Antiphospholipid (blood, immunology)
• Antiphospholipid Syndrome (blood, immunology)
• Autoantibodies (blood)
• Autoantigens (immunology)
• Autoimmune Diseases (blood, immunology)
• Female
• Humans
• Male
• Middle Aged