| Abstract |
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice. |
| Authors | Carl R Illig, Jinsheng Chen, Mark J Wall, Kenneth J Wilson, Shelley K Ballentine, M Jonathan Rudolph, Renee L DesJarlais, Yanmin Chen, Carsten Schubert, Ioanna Petrounia, Carl S Crysler, Christopher J Molloy, Margery A Chaikin, Carl L Manthey, Mark R Player, Bruce E Tomczuk, Sanath K Meegalla |
| Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 18
Issue 5
Pg. 1642-8
(Mar 01 2008)
ISSN: 1464-3405 [Electronic] England |
| PMID | 18242992
(Publication Type: Journal Article)
|
| Chemical References |
- Anti-Inflammatory Agents
- Collagen
- Receptor, Macrophage Colony-Stimulating Factor
|
| Topics |
- Animals
- Anti-Inflammatory Agents
(chemistry, pharmacology)
- Arthritis
(chemically induced, drug therapy)
- Collagen
- Dose-Response Relationship, Drug
- Mice
- Models, Molecular
- Molecular Structure
- Receptor, Macrophage Colony-Stimulating Factor
(antagonists & inhibitors)
- Structure-Activity Relationship
- Time Factors
|
