The well known association between
non-insulin dependent diabetes mellitus (
NIDDM) and
hyperlipoproteinemia (HLP) is one of the leading causes of high incidence and mortality for
cardiovascular disease of diabetic patients. For auspicious and effective treatment of
NIDDM and its complications,
secondary prevention, that is, an early detection, plays a major role. At the same time high concern should be given to the benefits of early detection and treatment of atherogenic HLP at early stages of
diabetes mellitus, for their occurrence in borderline impairment of
glucose tolerance (G-OGT) is still evasive. The investigation on the occurrence and incidence of HLP in G-OGT was carried out in 576 adults (310 men and 266 women) with recently detected G-OGT. The results were compared with those obtained in the non-G-OGT group (50 men and 52 women). Values of total
LDL cholesterol as well as
triglycerides in the blood of the subjects of either sex highly exceeded recommended values and were higher than in the controls.
HDL cholesterol was significantly decreased while the values of the
LDL cholesterol/
HDL cholesterol ratio and total
triglycerides were significantly higher. Atherogenic
hyperlipoproteinemia was evidenced in 52.58% of men and 50.75% of women with G-OGT and in 36.00% of men and 32.69% of women with normal G-OGT. After a one-year dietetic regimen all the
lipid parameters evidently improved in both men and women, while the incidence of atherogenic
hyperlipoproteinemia fell to 40.82% of the men and 31.32% of the women.