Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats.

Abstract

The antihyperlipidemic, antilipoperoxidative and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats were reported previously. The present study was undertaken to evaluate the preventive role of SACS on some biochemical parameters, glycoproteins and hematology in experimentally induced myocardial infarction in rats. Myocardial infarction was induced in rats by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days. ISO-treated rats showed a significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) in the heart and a significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+) and heart glycogen. The levels/concentrations of glycoproteins in serum and the heart were increased in myocardial infarcted rats. Myocardial infarcted rats also showed a significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count and fibrinogen level and a significant decrease in erythrocyte sedimentation rate, eosinophils, lymphocytes, bleeding, clotting and prothrombin time. Oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days showed a positive effect on all the biochemical parameters studied in ISO-induced rats. Thus, the study showed the protective effect of SACS on ISO-induced cardiotoxicity in male Wistar rats.

• Authors: T Sangeetha, S Darlin Quine
• Journal: Journal of applied toxicology : JAT (J Appl Toxicol) Vol. 28 Issue 5 Pg. 710-6 (Jul 2008) ISSN: 0260-437X [Print] England
• PMID: 18172887 (Publication Type: Journal Article)
• Copyright: 2008 John Wiley & Sons, Ltd

Chemical References

• Adrenergic beta-Agonists
• Cardiotonic Agents
• Glycoproteins
• alliin
• Cysteine
• Isoproterenol

Topics

• Adrenergic beta-Agonists
• Animals
• Blood Cell Count
• Blood Chemical Analysis
• Blood Coagulation (drug effects)
• Cardiotonic Agents
• Cysteine (analogs & derivatives, pharmacology)
• Glycoproteins (metabolism)
• Isoproterenol
• Male
• Myocardial Infarction (blood, chemically induced, prevention & control)
• Myocardium (enzymology, metabolism)
• Rats
• Rats, Wistar