Abstract | BACKGROUND: METHODS: In order to define these relationships within a group of older, obese adults, we studied 48 individuals (20 men; 71+/-1 years and 28 women; 65+/-1 years) who underwent a single, hyperinsulinemic, euglycemic clamp procedure, computed tomography scan at the L4-L5 level, and whole-body plethysmography or dual energy x-ray absorptiometry. Endogenous glucose production (basal glucose R(a)) was also measured at baseline and during the clamp procedure using an infusion of [6,6(2)H(2)] glucose. RESULTS: Mean body mass index (BMI; 31+/-1 kg/m(2)) and glycosylated hemoglobin A1c (HbA1c; 5.7+/-0.1%) levels were not significantly different between men and women. In men, there was an inverse relationship between SAF and insulin-stimulated glucose disposal (ISGD) (r= -.60, p=.01). In addition, there was a trend between thigh muscle attenuation and ISGD in men (r=.41, p=.07). Adiponectin was associated with ISGD in men (r=.46, p=.04) and women (r=.48, p =.01). There were no significant relationships between body fat distribution and basal glucose R(a) in men or women, and no relationships between triglycerides and glucose metabolism. CONCLUSIONS: Our results indicate that (i) SAF was negatively associated with ISGD in men, (ii) thigh muscle attenuation demonstrated a trend toward ISGD in men, and (iii) adiponectin was associated with ISGD in men and women.
|
Authors | Sophie E Yeo, Nicholas P Hays, Richard A Dennis, Patrick M Kortebein, Dennis H Sullivan, William J Evans, Robert H Coker |
Journal | The journals of gerontology. Series A, Biological sciences and medical sciences
(J Gerontol A Biol Sci Med Sci)
Vol. 62
Issue 12
Pg. 1393-401
(Dec 2007)
ISSN: 1079-5006 [Print] United States |
PMID | 18166691
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adipose Tissue
(metabolism)
- Aged
- Body Composition
- Cross-Sectional Studies
- Female
- Glucose
(metabolism)
- Humans
- Male
- Middle Aged
- Muscle, Skeletal
(pathology)
- Obesity
(metabolism)
- Triglycerides
(blood)
|