Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease.

Abstract

Dopamine agonists used to manage Parkinsonian motor symptoms have been suggested to be neuroprotective. The study was designed to assess the neuroprotective potential of the D(3)/D(2)/D(1) dopamine receptor agonist rotigotine in the acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned (MPTP) mouse model of Parkinson's disease by measuring mesencephalic degenerating neurons using FluoroJade staining and the remaining dopaminergic nerve endings in the striatum using dopamine transporter binding. Continuous administration of rotigotine at a dose of 3mg/kg significantly attenuated MPTP-induced acute cell degeneration in the FluoroJade-staining paradigm. Rotigotine (0.3-3mg/kg) partially protected dopamine nerve endings from MPTP-induced degeneration in a dose-dependent manner. These data suggest that rotigotine, at the doses employed, significantly protected dopamine neurons from degeneration in an acute mouse model of MPTP intoxication.

• Authors: Dieter Scheller, Christine Stichel-Gunkel, Hermann Lübbert, Gregory Porras, Paula Ravenscroft, Michael Hill, Erwan Bezard
• Journal: Neuroscience letters (Neurosci Lett) Vol. 432 Issue 1 Pg. 30-4 (Feb 13 2008) ISSN: 0304-3940 [Print] Ireland
• PMID: 18162314 (Publication Type: Journal Article)

Chemical References

• Dopamine Agonists
• Iodine Radioisotopes
• Neuroprotective Agents
• Receptors, Dopamine
• Tetrahydronaphthalenes
• Thiophenes
• rotigotine

Topics

• Acute Disease
• Administration, Cutaneous
• Animals
• Corpus Striatum (drug effects, metabolism)
• Dopamine Agonists (pharmacology)
• Dose-Response Relationship, Drug
• Iodine Radioisotopes
• Male
• Mice
• Mice, Inbred C57BL
• Nerve Degeneration (drug therapy, prevention & control)
• Neuroprotective Agents (pharmacology)
• Parkinsonian Disorders (drug therapy, prevention & control)
• Radioligand Assay
• Receptors, Dopamine (metabolism)
• Substantia Nigra (drug effects, metabolism)
• Tetrahydronaphthalenes (pharmacology)
• Thiophenes (pharmacology)