Abstract | OBJECTIVE: DESIGN: A prospective, multicenter, randomized, nonblinded clinical trial to compare 2 parallel groups of patients with bullous pemphigoid undergoing different treatments. SETTING: Thirteen departments of dermatology in Germany. PATIENTS: Patients with bullous pemphigoid (n = 73) as evidenced by clinical lesions suggestive of bullous pemphigoid, signs of subepidermal blistering on histologic analysis of skin biopsy specimens, linear deposition of IgG and C3 along the dermoepidermal junction, and deposition of autoantibodies at the blister roof in split-skin analysis. INTERVENTIONS: MAIN OUTCOME MEASURES: The cumulative total methylprednisolone doses and rates of remission. Secondary outcome measures were safety profiles and duration of remission. RESULTS: CONCLUSIONS:
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Authors | Stefan Beissert, Thomas Werfel, Uta Frieling, Markus Böhm, Michael Sticherling, Rudolf Stadler, Detlef Zillikens, Berthold Rzany, Nicolas Hunzelmann, Michael Meurer, Harald Gollnick, Thomas Ruzicka, Hans Pillekamp, Volker Junghans, Gisela Bonsmann, Thomas A Luger |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 143
Issue 12
Pg. 1536-42
(Dec 2007)
ISSN: 1538-3652 [Electronic] United States |
PMID | 18087004
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenal Cortex Hormones
- Glucocorticoids
- Immunosuppressive Agents
- Mycophenolic Acid
- Azathioprine
- Methylprednisolone
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Topics |
- Administration, Oral
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Aged
- Aged, 80 and over
- Azathioprine
(administration & dosage, adverse effects, therapeutic use)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects, therapeutic use)
- Male
- Methylprednisolone
(administration & dosage, adverse effects, therapeutic use)
- Middle Aged
- Mycophenolic Acid
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Patient Compliance
- Pemphigoid, Bullous
(drug therapy)
- Recurrence
- Remission Induction
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