Adipokines and cytokines in non-alcoholic fatty liver disease.

Abstract

BACKGROUND:

Several adipocytokines have been implicated in the pathogenesis non-alcoholic fatty liver disease (NAFLD).

AIM:

To assess adipocytokines in NAFLD patients and controls.

METHODS:

A total of 95 patients (26 non-alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non-obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and IL-6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations.

RESULTS:

Serum TNF-alpha and IL-8 were higher in NAFLD patients when compared with both obese and non-obese controls. Analysis involving all patients revealed a significant correlation between serum TNF-alpha and IL-8 (P < 6.319e-08), and between IL-6 and IL-8 (P < 5.271e-15). Homeostatic model assessment scores negatively correlated with adiponectin in NAFLD (P < 0.0032). Serum visfatin was higher in all three obese groups than in non-obese controls (P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF-alpha was associated with NAFLD (P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL-8 and adiponectin (P < 0.05). Multivariate analysis indicated that TNF-alpha was the only independent predictor of fibrosis in NASH (P < 0.0004).

CONCLUSION:

These findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.

• Authors: M H Jarrar, A Baranova, R Collantes, B Ranard, M Stepanova, C Bennett, Y Fang, H Elariny, Z Goodman, V Chandhoke, Z M Younossi
• Journal: Alimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 27 Issue 5 Pg. 412-21 (Mar 01 2008) ISSN: 1365-2036 [Electronic] England
• PMID: 18081738 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adipokines
• Adiponectin
• Blood Glucose
• Cytokines
• Insulin
• Interleukin-6
• Interleukin-8
• Resistin
• Tumor Necrosis Factor-alpha
• Nicotinamide Phosphoribosyltransferase

Topics

• Adipokines (blood)
• Adiponectin (blood)
• Adult
• Aged
• Biopsy
• Blood Glucose (analysis)
• Case-Control Studies
• Cohort Studies
• Cytokines (blood)
• Fasting
• Fatty Liver (blood, complications, etiology, surgery)
• Female
• Humans
• Immunoenzyme Techniques
• Insulin (blood)
• Insulin Resistance
• Interleukin-6 (blood)
• Interleukin-8 (blood)
• Linear Models
• Liver (surgery)
• Liver Cirrhosis (blood, pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Nicotinamide Phosphoribosyltransferase (blood)
• Obesity (complications)
• Resistin (blood)
• Tumor Necrosis Factor-alpha (blood)