Abstract | BACKGROUND: METHODS: RESULTS: Both MR-proADM and CT-proET-1 were able to differentiate patients with subsequent long-term clinical events (n=11) from those without (n=19). At the time of acute myocardial infarction, median MR-proADM level of the event group was 0.69 nmol/L as compared to 0.59 nmol/L of the no-event group (p=0.036). A difference was still observed after 3 days (event group median 0.66 nmol/L; no-event group median 0.57 nmol/L; p=0.022). Accordingly, median CT-proET-1 level was 72.9 pmol/L in the event group as compared to a median of 54.4 pmol/L in patients in the no-event group (p=0.009) 3 days after acute myocardial infarction. Within the acute phase, patients with MR-proADM levels > or =0.67 nmol/L were 3 times more likely (relative risk 2.8; 95% confidence interval 1.2-6.9; p=0.042) to suffer from a future clinical event. The area under the curve (AUC) was 0.71 (95% confidence interval 0.51-0.86; p=0.046). After 3 days, patients with CT-proET-1 levels > or =57 pmol/L were 6 times more likely (relative risk 5.9; 95% confidence interval 0.9-40.4; p=0.036) to suffer from a future clinical event. The AUC was 0.76 (95% confidence interval 0.55-0.90; p=0.015). CONCLUSIONS:
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Authors | Michael Behnes, Jana Papassotiriou, Thomas Walter, Esther Fiedler, Tamara Sauer, Siegfried Lang, Elif Elmas, Ursula Hoffmann, Martin Borggrefe, Martina Brueckmann |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 46
Issue 2
Pg. 204-11
( 2008)
ISSN: 1434-6621 [Print] Germany |
PMID | 18076360
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelin-1
- Adrenomedullin
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Topics |
- Adrenomedullin
(blood)
- Adult
- Aged
- Aged, 80 and over
- Endothelin-1
(blood)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, diagnosis)
- Prognosis
- Prospective Studies
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