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[Detection of mite allergens in the dust of filter-net and air of air-conditioned room].

AbstractOBJECTIVE:
To detect mite allergens in the dust of air conditioner filter-net and floating air in room.
METHODS:
Samples were collected from rooms of asthma patient and normal families with or without air conditioner. Der p1, Der f1 and Der 2 were determined by two monoclonal antibody-based ELISA.
RESULTS:
In asthma patient families, the concentration of airborne Der p1, Der f1 and Der 2 was (0.23 +/- 0.13), (2.62 +/- 1.08), (0.93 +/- 0.41) ng/m3, and (0.56 +/- 0.25), (4.74 +/- 1.22), (2.33 +/- 0.64) ng/m3 respectively before and after the air conditioner switched on, all showing a significant difference (P < 0.05). In families without asthma patient, the concentration of Der p1, Der f1 and Der 2 was (0.33 +/- 0.11), (11.50 +/- 3.08) and (2.10 +/- 0.80) ng/m3, and (0.63 +/- 0.23), (19.80 +/- 4.30) and (3.60 +/- 1.00) ng/m3 respectively before and after the air conditioner switched on, also showing a significant difference (P < 0.05). From the filter-net dust of air conditioner in family with allergic asthma patient, the concentration of Der p1, Der f1 and Der 2 was (0.52 +/- 0.19), (3.34 +/- 0.63), (2.53 +/- 0.65) microg/g dust, while that of normal families was (1.30 +/- 0.35), (5.16 +/- 0.92), (3.47 +/- 1.13) microg/g dust respectively. The concentration of Der f1 and Der 2 at both asthma families and normal families was higher than 2 microg/g, an allergen concentration threshold.
CONCLUSION:
Mite allergens exist in the filter-net dust of air conditioner, which may be an important source of indoor allergens and a cause of the increasing prevalence of allergic asthma.
AuthorsYu-yin Lian, Zhi-gang Liu, Hong-yu Wang, Cheng-yu Chai, Xiao-yu Liu
JournalZhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) Vol. 25 Issue 4 Pg. 325-7, 332 (Aug 2007) ISSN: 1000-7423 [Print] China
PMID18038805 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Air Pollutants
  • Allergens
  • Dust
Topics
  • Air Conditioning
  • Air Pollutants (analysis, isolation & purification)
  • Air Pollution, Indoor (analysis)
  • Allergens (analysis, isolation & purification)
  • Animals
  • Asthma (immunology)
  • Bedding and Linens
  • Dust (analysis)
  • Enzyme-Linked Immunosorbent Assay
  • Filtration (instrumentation)
  • Housing
  • Humans
  • Mites (immunology)

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