Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis.

Abstract

Heterogeneity in clinical disease course and histopathology complicates the treatment of multiple sclerosis. We detected important differences in neurodegeneration in various subtypes of myelin oligodendrocyte glycoprotein (MOG)-induced optic neuritis. Dark Agouti (DA) rats showed a significantly higher survival of retinal ganglion cells in comparison to Brown Norway rats. After surgical transection of the optic nerve neuronal loss was similar in both rat strains. We identified an increased expression of interleukin 1beta and glial cell line-derived neurotrophic factor in DA rats as the possible mechanism of the observed endogenous neuroprotection in MOG-induced optic neuritis.

• Authors: Muriel B Sättler, Mauro Togni, Ivana Gadjanski, Kurt-Wolfram Sühs, Nadine Meyer, Mathias Bähr, Ricarda Diem
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 193 Issue 1-2 Pg. 77-86 (Jan 2008) ISSN: 0165-5728 [Print] Netherlands
• PMID: 18037506 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glial Cell Line-Derived Neurotrophic Factor
• Interleukin-1beta
• Mog protein, rat
• Myelin Proteins
• Myelin-Associated Glycoprotein
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Animals
• Antibody Formation
• Autoimmune Diseases (etiology)
• CD4-Positive T-Lymphocytes (immunology)
• CD8-Positive T-Lymphocytes (immunology)
• Disease Models, Animal
• Disease Susceptibility
• Female
• Glial Cell Line-Derived Neurotrophic Factor (biosynthesis)
• Interleukin-1beta (biosynthesis)
• Multiple Sclerosis (etiology)
• Myelin Proteins
• Myelin-Associated Glycoprotein (immunology)
• Myelin-Oligodendrocyte Glycoprotein
• Neurodegenerative Diseases (etiology)
• Optic Neuritis (etiology, pathology)
• Rats
• Retinal Ganglion Cells (pathology)
• Species Specificity