Scleritis and peripheral ulcerative keratitis.

Abstract

Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and require early diagnosis and treatment. Nearly two thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy and one fourth need a glucocorticoid-sparing agent as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. A detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are important in the exclusion of underlying disorders and extraocular involvement.

• Authors: Anat Galor, Jennifer E Thorne
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 33 Issue 4 Pg. 835-54, vii (Nov 2007) ISSN: 0889-857X [Print] United States
• PMID: 18037120 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Glucocorticoids

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Arthritis, Rheumatoid (epidemiology)
• Comorbidity
• Corneal Ulcer (complications, drug therapy, epidemiology)
• Diagnosis, Differential
• Glucocorticoids (therapeutic use)
• Humans
• Scleritis (complications, diagnosis, drug therapy, epidemiology)