Abstract | OBJECTIVE: The aim of this study was to evaluate whether pretreatment with finasteride, a 5alpha-reductase inhibitor, improves immune functions after trauma- hemorrhage. SUMMARY BACKGROUND DATA: A number of studies have provided evidence for a gender dimorphism in host defense after trauma. Under stress conditions, such as trauma- hemorrhage, androgenic hormones have immunosuppressive effects, leading to increased susceptibility to sepsis, morbidity, and mortality. Testosterone is converted by 5alpha-reductase to 5alpha-dihydrotestosterone (DHT), a more potent androgen. METHODS: RESULTS: CONCLUSION: These results suggest that inhibition of 5alpha-reductase leads to the conversion of testosterone to 17beta-estradiol, which produces salutary effects on the post-traumatic immune response.
|
Authors | Michael Frink, Ya-Ching Hsieh, Shunhua Hu, Chi-Hsun Hsieh, Hans-Christoph Pape, Mashkoor A Choudhry, Martin G Schwacha, Kirby I Bland, Irshad H Chaudry |
Journal | Annals of surgery
(Ann Surg)
Vol. 246
Issue 5
Pg. 836-43
(Nov 2007)
ISSN: 0003-4932 [Print] United States |
PMID | 17968177
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- 5-alpha Reductase Inhibitors
- Cytokines
- Enzyme Inhibitors
- Estradiol
- Finasteride
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
|
Topics |
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
(blood)
- 5-alpha Reductase Inhibitors
- Animals
- Cytokines
(blood)
- Enzyme Inhibitors
(pharmacology, therapeutic use)
- Estradiol
(blood)
- Finasteride
(pharmacology, therapeutic use)
- Kupffer Cells
(drug effects, physiology)
- Male
- Mice
- Mice, Inbred C3H
- Neutrophil Infiltration
(drug effects, physiology)
- Pulmonary Edema
(blood, etiology, prevention & control)
- Shock, Hemorrhagic
(blood, immunology, prevention & control)
|