Iodine-123-interleukin-2 scintigraphy in metastatic hypernephroma: a pilot study.

Abstract

AIM:

This pilot study reports on the uptake of (123)I-interleukin 2 (IL-2) in metastatic renal cell carcinoma (MRCC) patients and its relationship to prognostic factors of response or failure of MRCC to cytokines treatment.

METHODS:

Nine consecutive patients with MRCC underwent an (123)I-IL-2 scan (6 male and 3 female; mean age 64 years; range 51-78). Uptake in metastases was related to a summed score of 4 independent factors, predictive of rapid progression under cytokine treatment as defined by Negrier et al.

RESULTS:

Four patients presented with metastases at one site, 4 at 2 sites and one patient at 3 different sites. Summed scores were: 5 patients had a summed score of 1; 3 a summed score of 2 and 1 patient a summed score of 3. Uptake of (123)I-IL-2 by tumor tissue was found in only 2 patients. Uptake occurred in 1 patient with a summed score of 3 and in 1 with a summed score of 2.

CONCLUSION:

In this small series of patients with MRCC, (123)I-IL-2 uptake was found in tumors of 2 patients who less likely will benefit from cytokine treatment. Additional studies are needed to assess the relationship between the pretreatment uptake of (123)/I-IL2 in MRCC and the response to IL-2 therapy.

• Authors: V Renard, L Staelens, A Signore, S Van Belle, R A Dierckx, C Van De Wiele
• Journal: The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (Q J Nucl Med Mol Imaging) Vol. 51 Issue 4 Pg. 352-6 (Dec 2007) ISSN: 1824-4785 [Print] Italy
• PMID: 17923825 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Interleukin-2
• Radiopharmaceuticals

Topics

• Aged
• Carcinoma, Renal Cell (diagnostic imaging, metabolism, secondary)
• Female
• Humans
• Interleukin-2 (pharmacokinetics)
• Kidney Neoplasms (diagnostic imaging, metabolism)
• Male
• Metabolic Clearance Rate
• Middle Aged
• Pilot Projects
• Radionuclide Imaging
• Radiopharmaceuticals (pharmacokinetics)
• Reproducibility of Results
• Sensitivity and Specificity
• Tissue Distribution