Renewed hope for a vaccine against the intestinal adult Taenia solium.

Abstract

Review of experimental and observational evidence about various cestode infections of mammalian hosts revives hope for the development of an effective vaccine against adult intestinal tapeworms, the central protagonists in their transmission dynamics. As for Taenia solium, there are abundant immunological data regarding cysticercosis in humans and pigs, but information about human taeniasis is scarce. A single publication reporting protection against T. solium taeniasis by experimental primo infection and by vaccination of an experimental foster host, the immunocompetent female hamster, kindles the hope of a vaccine against the tapeworm to be used in humans, its only natural definitive host.

• Authors: Edda Sciutto, Gabriela Rosas, Carmen Cruz-Revilla, Andrea Toledo, Jacquelynne Cervantes, Marisela Hernández, Beatríz Hernándezt, Fernando A Goldbaum, Aline S de Aluja, Gladis Fragoso, Carlos Larralde
• Journal: The Journal of parasitology (J Parasitol) Vol. 93 Issue 4 Pg. 824-31 (Aug 2007) ISSN: 0022-3395 [Print] United States
• PMID: 17918361 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anthelmintics
• Vaccines

Topics

• Animals
• Anthelmintics (therapeutic use)
• Carrier State (drug therapy, prevention & control)
• Humans
• Intestinal Diseases, Parasitic (prevention & control)
• Taenia solium (immunology)
• Taeniasis (drug therapy, prevention & control)
• Vaccines