Abstract | BACKGROUND: METHODS: Thirty Wistar male rats were randomly divided into COPD group (group C, n = 10), saline solution parallel group (group P, n = 8), and normal control group (group N, n = 8). Group C was challenged with passive cigarette smoking and intratracheal instillation of lipopolysaccharide. Six weeks later pulmonary functions were tested, bronchoalveolar fluid and arterial blood gases were assayed, and histopathological evaluations were performed in turn. The expressions of TACE, TNF-alpha and ErbB3 in lungs of all rats were determined histochemically. RESULTS: The expressions of TACE, TNF-alpha and ErbB3 were significantly higher in group C than in group N (P < 0.01). The contents of TNF-alpha in serum (P < 0.01) and bronchoalveolar lavage fluid (BALF) (P < 0.01) were elevated more significantly in group C than in group N. A positive correlation existed between TACE and TNF-alpha (r = 0.784, P < 0.01) and between TACE and ErbB3 (r = 0.526, P < 0.01) respectively. CONCLUSIONS:
TNF-alpha and ErbB3 are involved in the pathogenesis of COPD. TACE contributes to the progress of COPD indirectly through the function of TNF-alpha and ErbB3.
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Authors | Chun-rong Ju, Xi-zheng Xia, Rong-chang Chen |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 120
Issue 17
Pg. 1505-10
(Sep 05 2007)
ISSN: 0366-6999 [Print] China |
PMID | 17908459
(Publication Type: Journal Article)
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Chemical References |
- Tumor Necrosis Factor-alpha
- Receptor, ErbB-3
- ADAM Proteins
- ADAM17 Protein
- Adam17 protein, rat
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Topics |
- ADAM Proteins
(analysis, physiology)
- ADAM17 Protein
- Animals
- Bronchoalveolar Lavage Fluid
(chemistry)
- Immunohistochemistry
- Lung
(physiopathology)
- Male
- Pulmonary Disease, Chronic Obstructive
(metabolism, pathology)
- Rats
- Rats, Wistar
- Receptor, ErbB-3
(analysis, physiology)
- Tumor Necrosis Factor-alpha
(analysis)
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