High-dose chemotherapy and autologous bone marrow transplantation in relapsing angioimmunoblastic lymphadenopathy with dysproteinemia (AILD).

Abstract

Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) or lymphogranulomatosis X is a lymphoproliferative disorder with a histological picture resembling that of reactive lesions but with frequent cytogenetic and molecular abnormalities characteristic of malignant T cell lymphoma. Clinically, the disease runs a fatal course in the majority of patients although occasional spontaneous remissions have been observed. Median survival approaches only 1 year even with the most effective treatment protocols implemented so far. Fewer than 20% of patients survive 5 years after diagnosis and cure seems exceedingly rare. High-dose chemotherapy (HDCT) followed by autologous bone marrow transplantation (ABMT) represents a promising new treatment modality for patients with advanced lymphoma conceivably including AILD. We report the first patient with relapsed AILD successfully treated by HDCT and ABMT. This 21-year-old male is alive and free of disease 27 months after ABMT with a Karnofsky score of 100%.

• Authors: N Schmitz, E Prange, T Haferlach, H Griesser, R Sonnen, B Schlegelberger, S Claus, H Löffler
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 8 Issue 6 Pg. 503-6 (Dec 1991) ISSN: 0268-3369 [Print] England
• PMID: 1790431 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Blood Protein Disorders (complications, metabolism)
• Bone Marrow Transplantation
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Dose-Response Relationship, Drug
• Doxorubicin (administration & dosage)
• Humans
• Immunoblastic Lymphadenopathy (complications, metabolism, therapy)
• Male
• Prednisone (administration & dosage)
• Recurrence
• Transplantation, Autologous
• Vincristine (administration & dosage)