Abstract | AIMS: METHODS: Median follow-up was 3.9 years. Cox regression models were used to estimate the effect of atorvastatin on stroke rate and risk of stroke associated with baseline risk factors. Risk factors that predicted stroke in univariate models were examined in a multivariable model. RESULTS: Independent risk factors predicting stroke were age [10-year increments; hazard ratio (HR) 2.3, P < 0.001], microalbuminuria ( albumin : creatinine ratio > 2.5 mg/mmol; HR 2.0, P = 0.007) and glycaemic control (HbA(1c) > 10%; HR 2.7, P = 0.007). Women were at lower risk of stroke (HR 0.3, P = 0.004). Lipids did not predict stroke. Of 60 first strokes, 47 were non-haemorrhagic, 13 were indeterminate and none was definitely haemorrhagic. Atorvastatin treatment was associated with 50% reduction in non-haemorrhagic stroke (95% confidence interval 9%-72%P = 0.024), similar to the 48% reduction (11%-69%) for all strokes combined. CONCLUSIONS: Diabetes-specific risk factors are important predictors of stroke in Type 2 diabetes. Despite the lack of association between baseline lipids and first stroke, there was a reduction of 50% of non-haemorrhagic strokes associated with atorvastatin treatment in the CARDS population.
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Authors | G A Hitman, H Colhoun, C Newman, M Szarek, D J Betteridge, P N Durrington, J Fuller, S Livingstone, H A W Neil, CARDS Investigators |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 24
Issue 12
Pg. 1313-21
(Dec 2007)
ISSN: 0742-3071 [Print] England |
PMID | 17894827
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Glycated Hemoglobin A
- Heptanoic Acids
- Lipoproteins
- Pyrroles
- Atorvastatin
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Topics |
- Adult
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Atorvastatin
- Blood Pressure
- Diabetes Mellitus, Type 2
(blood, complications)
- Diabetic Angiopathies
(prevention & control)
- Double-Blind Method
- Female
- Glycated Hemoglobin
(analysis)
- Heptanoic Acids
(therapeutic use)
- Humans
- Lipoproteins
(blood)
- Male
- Middle Aged
- Pyrroles
(therapeutic use)
- Risk Factors
- Stroke
(etiology, prevention & control)
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