Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment.

Abstract

G1 cytostatic drugs reduce CCR5 co-receptor expression and enhance the antiviral activity of a CCR5 antagonist in vitro. The administration of rapamycin, a G1 cytostatic agent, to three cynomolgous macaques led to decreased CCR5 messenger RNA expression in peripheral blood mononuclear cells and cervicovaginal tissue. These results support further clinical evaluation of G1 cytostatic agents such as rapamycin targeting the downregulation of CCR5 expression as a strategy for both the prevention and treatment of HIV infection.

• Authors: Bruce L Gilliam, Alonso Heredia, Anthony Devico, Nhut Le, Douty Bamba, Joseph L Bryant, C David Pauza, Robert R Redfield
• Journal: AIDS (London, England) (AIDS) Vol. 21 Issue 15 Pg. 2108-10 (Oct 01 2007) ISSN: 0269-9370 [Print] England
• PMID: 17885304 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• RNA, Messenger
• Receptors, CCR5
• Sirolimus

Topics

• Animals
• Female
• Immunosuppressive Agents (pharmacology)
• Macaca
• RNA, Messenger (metabolism)
• Receptors, CCR5 (genetics, metabolism)
• Sirolimus (pharmacology)