The effect of substituents on the carcinogenicity of n-nitrosopyrrolidine in Sprague-Dawley rats.

Abstract

N-Nitrosopyrrolidine and two of its derivatives were prepared and fed in drinking water to Sprague-Dawley rats to compare the effects of substituents on the carcinogenicity of the N-nitrosopyrrolidine molecule. 3,4-Dichloro-N-nitrosopyrrolidine induced esophageal tumors in 13 of 14 animals, olfactory carcinomas in 4, and a hepatocellular tumor in 1. All animals that received this compound were dead at 55 weeks after the start of the experiments. N-Nitrosopyrrolidine induced hepatocellular tumors in 26 of 29 animals and induced 1 olfactory carcinoma. Not all animals in this group were dead until 104 weeks of the experiment. 2,5-Dimethyl-N-nitrosopyrrolidine induced only 2 hepatocellular tumors in 29 animals. The alpha-methyl substitution diminished the liver carcinogenicity, while the beta chlorine substitution affected a different target organ, the esophagus, and greatly reduced the time to death with tumors.

• Authors: W Lijinsky, H W Taylor
• Journal: Cancer research (Cancer Res) Vol. 36 Issue 6 Pg. 1988-90 (Jun 1976) ISSN: 0008-5472 [Print] United States
• PMID: 178438 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitrosamines
• Pyrrolidines

Topics

• Animals
• Carcinoma, Hepatocellular (chemically induced)
• Esophageal Neoplasms (chemically induced)
• Female
• Liver Neoplasms (chemically induced)
• Male
• Neoplasms, Experimental (chemically induced)
• Nitrosamines (chemical synthesis, toxicity)
• Nose Neoplasms (chemically induced)
• Pyrrolidines (chemical synthesis, toxicity)
• Rats