Abstract | BACKGROUND: METHODS: Blood samples were collected for 637 prostate cancer cases and 244 age and race frequency matched controls. In analysis, the SRD5A2 VL and LL genotypes were combined into one group and the HSD3B2 repeat polymorphism was dichotomized into short (<283) and long (> or =283) alleles. RESULTS: The SRD5A2 V89L polymorphism was not independently associated with prostate cancer risk. Carriage of at least one HSD3B2 intron 3 intron 3 short allele was associated with a significant increased risk for prostate cancer among all subjects (OR = 2.07, 95% CI = 1.08-3.95, P = 0.03) and Caucasians (OR = 2.80, CI = 2.80-7.43, P = 0.04), but not in African Americans (OR = 1.50, CI = 0.62-3.60, P = 0.37). Stratified analyses revealed that most of the prostate cancer risk associated with the intron 3 HSD3B2 short allele was confined to the SRD5A2 89L variant subgroup and indicated that in combination these polymorphisms may be associated with increased risk of aggressive (Gleason >7) disease (Gleason >7). CONCLUSIONS: In Caucasians, the HSD3B2 (TG)n,(TA)n,(CA)n intron 3 length polymorphism is associated with both prostate cancer risk and aggressiveness and the SRD5A2 V89L polymorphism may modify the risk conferred by this polymorphism.
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Authors | Christine Neslund-Dudas, Cathryn H Bock, Kristin Monaghan, Nora L Nock, James J Yang, Andrew Rundle, Deliang Tang, Benjamin A Rybicki |
Journal | The Prostate
(Prostate)
Vol. 67
Issue 15
Pg. 1654-63
(Nov 01 2007)
ISSN: 0270-4137 [Print] United States |
PMID | 17823934
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- DNA-Binding Proteins
- SPATA7 protein, human
- 3-Hydroxysteroid Dehydrogenases
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
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Topics |
- 3-Hydroxysteroid Dehydrogenases
(blood, genetics)
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
(genetics)
- Adenocarcinoma
(blood, diagnosis, ethnology, genetics)
- Black or African American
(ethnology, genetics)
- Aged
- DNA-Binding Proteins
(blood, genetics)
- Genetic Predisposition to Disease
(epidemiology)
- Humans
- Male
- Michigan
(epidemiology)
- Middle Aged
- Polymorphism, Genetic
- Population Surveillance
- Prognosis
- Prostatic Neoplasms
(blood, diagnosis, ethnology, genetics)
- Risk Factors
- White People
(ethnology, genetics)
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