Abstract |
Most of the methoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf thymus DNA. Tetramethoxy-8-oxoberbine 3f shows an inhibition of cell proliferation of 87% at a concentration of 10(-5) mole; its cytostatic effect does not depend on intercalation into DNA.
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Authors | C Weimar, S von Angerer, W Wiegrebe |
Journal | Archiv der Pharmazie
(Arch Pharm (Weinheim))
Vol. 324
Issue 8
Pg. 509-18
(Aug 1991)
ISSN: 0365-6233 [Print] Germany |
PMID | 1781733
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Berberine Alkaloids
- DNA
- Ethidium
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Berberine Alkaloids
(chemical synthesis, pharmacology)
- DNA
(chemistry, drug effects)
- Ethidium
- Humans
- Spectrometry, Fluorescence
- Spectrophotometry, Ultraviolet
- Tumor Cells, Cultured
(drug effects)
- Viscosity
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