| Abstract | OBJECTIVE: To study the inhibitory effect of extracts from Actinidia arguta by n-butyl alcohol on human carcinoma of esophagus cells (Eca-109) and Its mechanism. METHODS: MTT colonmetric assay was used to examine the growth inhibitory of concentration-effect (1 microg/ml, 10 microg/ml,100 microg/ml) and time-effect (24 h, 48 h, 72 h) of extracts from Actinidia arguta by n-butyl alcohol on Eca-109 cells. TUNEL test were performed to observe the apoptosis induced by the extracts (1 microg/ml, 10 microg/ml, 100 microg/ml) on Eca-109 cells. RESULTS: The inhibitory effect of the extracts on Eca-109 cells increased in a dose-time Manner and the highest rate of inhibition was 87.2%. The extracts could significantly induce apoptosis of Eca-109 cells, but in control group, apoptosis wasn't observed. CONCLUSION: The extracts from Actinidia arguta by n-butyl alcohol have good inhibitory effect on Eca-109 cells. |
| Authors | Li Zhang, Hong-Li Guo, Lin Tian, Shu-Fen Cao, Chang-Hai Du
(Affiliation: Dept of Pathology, Yunyang Medical College Affiliated People's Hospital, Shiyan 442000, China.)
|
| Journal | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
(Zhong Yao Cai)
Vol. 30
Issue 5
Pg. 564-6
(May 2007)
ISSN: 1001-4454 China |
| PMID | 17727063
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Drugs, Chinese Herbal
|
| Topics |
- Actinidia
(chemistry)
- Antineoplastic Agents, Phytogenic
(administration & dosage, pharmacology)
- Apoptosis
(drug effects)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
(administration & dosage, pharmacology)
- Esophageal Neoplasms
(pathology)
- Humans
- Plant Roots
(chemistry)
- Plants, Medicinal
(chemistry)
- Time Factors
|
