Maxadilan, a PAC1 receptor agonist from sand flies.

Abstract

In 1991, a potent 61 amino acid vasodilator peptide, named maxadilan, was isolated from the salivary glands of the sand fly. Subsequently, it was shown that this peptide specifically and potently activated the mammalian PAC1 receptor, one of the three receptors for PACAP. These studies and the link between maxadilan and leishmaniasis are discussed.

• Authors: Ethan A Lerner, Aurel O Iuga, Vemuri B Reddy
• Journal: Peptides (Peptides) Vol. 28 Issue 9 Pg. 1651-4 (Sep 2007) ISSN: 0196-9781 [Print] United States
• PMID: 17681401 (Publication Type: Journal Article, Review)

Chemical References

• Insect Proteins
• Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
• maxadilan protein, Lutzomyia longipalpis
• maxadilan protein, insect

Topics

• Animals
• Diptera (metabolism)
• Insect Proteins (chemistry, pharmacology)
• Insect Vectors (metabolism)
• Leishmaniasis (transmission)
• Protein Structure, Secondary
• Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I (agonists)