Nodular Hyperplasia of the Bartholin Gland: A Clinicopathological Study of Two Cases, Including Detection of Clonality by HUMARA.

Abstract	The authors report two examples of nodular hyperplasia of the Bartholin gland. Each occurred in the vulva, close to the introitus of women aged 33 and 49 years, who presented with slightly painful lesions that were clinically thought to be cysts. Grossly, both masses exhibited a multilobular architecture, were elastic, were gray in color, and measured 4 cm and 3.2 cm in greatest dimension. On microscopic examination, the lesions looked similar and exhibited an increased number of secretory acini, with maintenance of the normal duct-acinar relationship--features compatible with nodular hyperplasia. Rare dilated ducts were observed, and intraluminal inspissated secretions were occasionally seen. In one case, there were a focal mild inflammatory infiltrate, squamous metaplasia of larger ducts, and rare ruptured ducts with extravasated stromal mucin. Clonality analysis performed in one case revealed a monoclonal pattern, suggesting that the lesion may be a neoplastic process rather than simple reactive hyperplasia.
Authors	Dmitry V Kazakov, Romuald Curik, Tomas Vanecek, Petr Mukensnabl, Michal Michal
Journal	The American Journal of dermatopathology (Am J Dermatopathol) Vol. 29 Issue 4 Pg. 385-7 (Aug 2007) ISSN: 0193-1091 [Print] United States
PMID	17667173 (Publication Type: Case Reports, Journal Article)
Chemical References	AR protein, human Actins CKAP4 protein, human Calcium-Binding Proteins Membrane Proteins Microfilament Proteins Mucins Muscle Proteins Receptors, Androgen S100 Proteins Keratins Collagen
Topics	Actins (analysis) Adult Bartholin's Glands (metabolism, pathology) Calcium-Binding Proteins (analysis) Clone Cells (pathology) Collagen (ultrastructure) Cytoplasm (ultrastructure) Dilatation, Pathologic (pathology) Female Humans Hyperplasia Keratins (analysis) Membrane Proteins (analysis) Metaplasia Microfilament Proteins (analysis) Middle Aged Mucins (metabolism) Muscle Proteins (analysis) Receptors, Androgen (analysis) S100 Proteins (analysis) Calponins

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