Brain tau expression and correlation with the H1/H1 tau genotype in frontotemporal lobar degeneration patients.

Abstract

Alterations in tau mRNA splicing and association with H1/H1 tau genotype have been described in some sporadic tauopathies. We evaluated the 4R/3R tau mRNA ratio in 18 patients with frontotemporal lobar degeneration (FTLD), and the effect of the H1/H1 genotype on this ratio. The 4R/3R mRNA ratio in frontal cortex was similar in FTLD patients and controls. The H1/H1 genotype carriers showed a significant increase in 4R/3R mRNA ratio, suggesting that this genotype could modulate the tau mRNA splicing.

• Authors: A Lladó, M Ezquerra, C Gaig, R Sánchez-Valle, E Tolosa, J L Molinuevo
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 114 Issue 12 Pg. 1585-8 ( 2007) ISSN: 0300-9564 [Print] Austria
• PMID: 17661153 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protein Isoforms
• RNA, Messenger
• tau Proteins

Topics

• Aged
• Aged, 80 and over
• Alternative Splicing
• Brain (pathology)
• Dementia (genetics, pathology)
• Female
• Gene Expression
• Genotype
• Humans
• Male
• Middle Aged
• Protein Isoforms (biosynthesis)
• RNA, Messenger (analysis)
• Reverse Transcriptase Polymerase Chain Reaction
• tau Proteins (biosynthesis, genetics)