Abstract | PURPOSE: To report the long-term results and examine factors associated with bladder preservation, risk of relapse, and survival in patients treated with radical radiotherapy for invasive bladder cancer. MATERIALS AND METHODS: RESULTS: The median age of patients was 71 years, 13% had evidence of regional lymph node involvement, and 27% were medically unfit for radical cystectomy. A total of 247 patients received radiotherapy alone, 36 radiotherapy and concurrent cisplatin chemotherapy, and 57 neoadjuvant chemotherapy followed by radiotherapy. Complete response was obtained in 63.5% of patients overall, and median follow-up was 7.9 years. The 10-year overall survival, cause-specific survival, and local relapse-free rates were 19%, 35%, and 32%, respectively. In 131 patients with muscle-invasive disease confined to the bladder wall (T2N0M0), 10-year cause-specific survival (P = 0.02) and local relapse-free rates (P = 0.03) were 68% and 60% when carcinoma in situ was absent, and 47% and 28%, respectively, when present. In multivariable analysis, younger age, lower T category, and absence of carcinoma in situ were associated with a statistically significant improvement in survival and local control (P <or= 0.01). The majority of survivors beyond 5 years had an intact bladder. CONCLUSIONS:
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Authors | Peter W M Chung, Robert G Bristow, Michael F Milosevic, Qi-long Yi, Michael A S Jewett, Padraig R Warde, Charles N Catton, Michael McLean, Malcolm Moore, Ian F Tannock, Mary K Gospodarowicz |
Journal | Urologic oncology
(Urol Oncol)
2007 Jul-Aug
Vol. 25
Issue 4
Pg. 303-9
ISSN: 1078-1439 [Print] United States |
PMID | 17628296
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Transitional Cell
(mortality, physiopathology, radiotherapy)
- Cystectomy
- Disease-Free Survival
- Female
- Follow-Up Studies
- Humans
- Lymphatic Metastasis
- Male
- Middle Aged
- Muscle, Smooth
(physiopathology)
- Neoplasm Recurrence, Local
- Survival Rate
- Treatment Outcome
- Urinary Bladder
(physiopathology)
- Urinary Bladder Neoplasms
(mortality, physiopathology, radiotherapy)
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