In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection.

Abstract

A novel oxazolidinone, AM 7359, was evaluated in two mouse models of Staphylococcus aureus infection. AM 7359 and linezolid were equally efficacious in a methicillin-susceptible S. aureus organ burden model and a methicillin-resistant S. aureus localized infection model. However, AM 7359 was eightfold more efficacious than linezolid against a linezolid- and methicillin-resistant S. aureus strain in this localized (thigh) infection model.

• Authors: Charles J Gill, George K Abruzzo, Amy M Flattery, Andrew S Misura, Ken Bartizal, Emily J Hickey
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 51 Issue 9 Pg. 3434-6 (Sep 2007) ISSN: 0066-4804 [Print] United States
• PMID: 17606686 (Publication Type: Journal Article)

Chemical References

• AM-7359
• Acetamides
• Anti-Bacterial Agents
• Oxazolidinones
• Linezolid

Topics

• Acetamides (therapeutic use)
• Administration, Oral
• Animals
• Anti-Bacterial Agents (therapeutic use)
• Colony Count, Microbial
• Dose-Response Relationship, Drug
• Injections, Intravenous
• Linezolid
• Methicillin Resistance
• Mice
• Mice, Inbred C3H
• Oxazolidinones (therapeutic use)
• Staphylococcal Infections (drug therapy, microbiology)