Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.

Abstract

The effects of chronic combined treatment with alpha7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or alpha7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17beta-estradiol (0.5 microg per rat intramuscularly) for 10 days on passive avoidance retention were studied in middle-aged (15 months) ovariectomized rats with experimental Alzheimer type dementia. Chronic treatment with RJR-2403 and 17beta-estradiol had a pronounced antiamnestic effect under conditions of Alzheimer type dementia in middle-aged ovariectomized rats.

• Authors: N S Sapronov, Yu O Fedotova, N N Kuznetsova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 142 Issue 6 Pg. 700-2 (Dec 2006) ISSN: 0007-4888 [Print] United States
• PMID: 17603674 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nicotinic Agonists
• Receptors, Nicotinic
• Estradiol
• metanicotine
• Mecamylamine
• Nicotine
• Acetylcholine

Topics

• Acetylcholine (pharmacology)
• Alzheimer Disease (complications, drug therapy)
• Amnesia (chemically induced, drug therapy)
• Animals
• Avoidance Learning (drug effects)
• Drug Therapy, Combination
• Estradiol (therapeutic use)
• Female
• Mecamylamine (therapeutic use)
• Nicotine (analogs & derivatives, pharmacology, therapeutic use)
• Nicotinic Agonists (pharmacology)
• Ovariectomy
• Rats
• Rats, Wistar
• Receptors, Nicotinic (drug effects, physiology)