Abstract | BACKGROUND: METHODS AND RESULTS: All Olmsted County residents who had a myocardial infarction meeting standardized criteria were prospectively enrolled to measure CRP on admission and followed for heart failure and death. A total of 329 consecutive patients (mean age 69 +/- 16 years, 52% men) were enrolled. At 1 year, 28% of patients experienced heart failure and 20% died. There was a strong positive graded association between CRP and the risk of developing heart failure, as well as dying over the period of follow-up (P < .001). Compared with patients in the first tertile, patients in the third tertile of the CRP distribution had a markedly increased risk of heart failure and death independently of age, sex, troponin T, Q wave, comorbidity, previous myocardial infarction, and recurrent ischemic events (adjusted hazard ratio 2.47 [95% confidence interval, 1.27-4.82] for heart failure and 3.96 [95% confidence interval, 1.78-8.83] for death). CONCLUSIONS:
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Authors | Francesca Bursi, Susan A Weston, Jill M Killian, Sherine E Gabriel, Steven J Jacobsen, Véronique L Roger |
Journal | The American journal of medicine
(Am J Med)
Vol. 120
Issue 7
Pg. 616-22
(Jul 2007)
ISSN: 1555-7162 [Electronic] United States |
PMID | 17602936
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- C-Reactive Protein
(analysis)
- Female
- Heart Failure
(blood, etiology, mortality)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(blood, complications)
- Prospective Studies
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