Abstract | OBJECTIVE: Recently we reported that human immunodeficiency virus (HIV)-infected Caucasian men treated with highly active antiretroviral therapy ( HAART) have normal weight-adjusted bone mineral density (BMD), in contrast to most other cross-sectional analyses, which have reported low BMD in HIV-infected patients. We have now addressed the question of whether there is accelerated BMD loss over time in HIV-infected men. DESIGN: A 2-year, prospective, longitudinal study. SUBJECTS: Twenty-three HAART-treated, HIV-infected men and 26 healthy controls. MEASUREMENTS: All participants had measurements of BMD and bone-related laboratory parameters at baseline, and a repeat measurement of BMD at 2 years. RESULTS: In the HIV-infected men the mean age was 47 years, the mean duration of infection was 8.2 years, and the mean duration of HAART was 54 months. Over 2 years of follow-up, BMD increased from baseline in the HIV-infected men by 2.6% at the lumbar spine (P = 0.05 vs. baseline), and remained stable at the total hip (mean change 0.1%, P > 0.99) and total body (mean change 0.6%, P = 0.39). Mean changes in BMD in the control group were 1.4% at the lumbar spine, -0.1% at the total hip, and -0.8% at the total body. The HIV-infected men lost less total body BMD than the control group (P = 0.01). In the HIV-infected men, body weight remained stable over 2 years while fat mass decreased and lean mass tended to increase, whereas in the controls, body weight and fat mass increased while lean mass remained stable. CONCLUSIONS: Accelerated bone loss does not occur in HIV-infected men treated with HAART. Monitoring of BMD in HIV-infected men may not be necessary.
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Authors | Mark J Bolland, Andrew B Grey, Anne M Horne, Simon E Briggs, Mark G Thomas, Rod B Ellis-Pegler, Andrew F Woodhouse, Greg D Gamble, Ian R Reid |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 67
Issue 2
Pg. 270-5
(Aug 2007)
ISSN: 0300-0664 [Print] England |
PMID | 17547686
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Anti-HIV Agents
(therapeutic use)
- Antiretroviral Therapy, Highly Active
- Body Composition
- Bone Density
(physiology)
- Case-Control Studies
- Chi-Square Distribution
- HIV Infections
(drug therapy, physiopathology)
- HIV-1
- Humans
- Male
- Middle Aged
- Prospective Studies
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